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凋亡抑制因子IASPP抗體
  • 產(chǎn)品貨號(hào)：
    BN41524R
  • 中文名稱：
    凋亡抑制因子IASPP抗體
  • 英文名稱：
    Rabbit anti-IASPP Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41524R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Sheep,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41524R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Sheep,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41524R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Sheep,GuineaPig) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱IASPP
中文名稱凋亡抑制因子IASPP抗體
別    名IASPP; inhibitor of apoptosis stimulating protein of p53; Inhibitor of ASPP protein; NFkB interacting protein 1; NKIP1; PPP1R13B-like protein; PPP1R13L; Protein iASPP; protein phosphatase 1 regulatory (inhibitor) subunit 13 like; RAI; RelA-associated inhibitor; IASPP_HUMAN; RelA-associated inhibitor; Inhibitor of ASPP protein; NFkB-interacting protein 1.  
研究領(lǐng)域腫瘤  免疫學(xué)  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Dog, Cow, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量89kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 細(xì)胞外基質(zhì) 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IASPP:15-100/828 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹iASPP(inhibitor of apoptosis stimulating protein of p53)regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. Belongs to the ASPP family.

Function:
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

Subunit:
Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.

Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.

Tissue Specificity:
Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.

Similarity:
Belongs to the ASPP family.
Contains 2 ANK repeats.
Contains 1 SH3 domain.

SWISS:
Q8WUF5

Gene ID:
10848

Database links:

Entrez Gene: 10848 Human

Entrez Gene: 333654 Mouse

Omim: 607463 Human

SwissProt: Q8WUF5 Human

SwissProt: Q3TCU2 Mouse

SwissProt: Q5I1X5 Mouse

Unigene: 466937 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IASPP(inhibitory member of the ASPP family) 是新近發(fā)現(xiàn)的高度保守的p53相關(guān)基因, 是細(xì)胞凋亡ASPP家族的另一個(gè)成員。
iASPP能夠抑制ASPP1，2的促凋亡作用，其蛋白產(chǎn)物定位于細(xì)胞核內(nèi),具有結(jié)合NF-κB p65亞基和p53功能,進(jìn)而抑制NF-κB的轉(zhuǎn)錄調(diào)節(jié)和p53對(duì)凋亡的調(diào)節(jié)功能。
研究者發(fā)現(xiàn)iASPP蛋白，能夠干擾p53基因發(fā)揮正常的促使細(xì)胞死亡的作用。這就意味著iASPP在正常細(xì)胞轉(zhuǎn)化為癌癥細(xì)胞方面起著重要的促進(jìn)作用，即iASPP具有促進(jìn)癌變的功能。表達(dá)位置：細(xì)胞漿，部分細(xì)胞核。
inhibitor of ASPP