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胎盤生長(zhǎng)因子抗體
  • 產(chǎn)品貨號(hào)：
    BN41516R
  • 中文名稱：
    胎盤生長(zhǎng)因子抗體
  • 英文名稱：
    Rabbit anti-PLGF Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41516R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human(predicted:Mouse) 推薦應(yīng)用：WB,ELISA

  • BN41516R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse) 推薦應(yīng)用：WB,ELISA

  • BN41516R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱PLGF
中文名稱胎盤生長(zhǎng)因子抗體
別    名Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein.  
研究領(lǐng)域腫瘤  心血管  生長(zhǎng)因子和激素  血管內(nèi)皮細(xì)胞  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse PLGF:131-158/158 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The placental-derived growth factor (PIGF) is a dimeric glycoprotein showing a high degree of sequence similarity to the vascular endothelial growth factor. Alternative splicing of the PIGF primary transcript gives rise to two forms, named PIGF-1 and PIGF-2, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. The presence of the PIGF mRNA in thyroid, placenta, lung, and goiter has indicated the tissues where this factor functions. However, the role of PIGF in vascular development has not yet been clearly established.

Function:
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.

Subunit:
Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF (By similarity).

Subcellular Location:
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.

Tissue Specificity:
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

SWISS:
P49763

Gene ID:
18654

Database links:

Entrez Gene: 5228 Human

Entrez Gene: 18654 Mouse

Omim: 601121 Human

SwissProt: P49763 Human

SwissProt: P49764 Mouse

Unigene: 252820 Human

Unigene: 4809 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PLGF胎盤生長(zhǎng)因子是血管生長(zhǎng)因子家族成員之一，是動(dòng)脈粥樣硬化斑塊不穩(wěn)定的主要炎性激活物，因此它可作為ACS患者風(fēng)險(xiǎn)預(yù)測(cè)的生物學(xué)標(biāo)志物.尿胎盤生長(zhǎng)因子水平可預(yù)測(cè)先兆子癇危險(xiǎn).研究人員發(fā)現(xiàn)，在疾病發(fā)作前的6到8周，先兆子癇患者尿液中的胎盤生長(zhǎng)因子水平急劇下降,這種新的尿檢方法使提前1到2個(gè)月預(yù)測(cè)先兆子癇成為可能。亦有研究人員正在從事胎盤生長(zhǎng)因子與肺氣腫，胃癌，腸癌等方面的研究。