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半胱胺酸蛋白酶蛋白-6抗體
  • 產品貨號：
    BN41482R
  • 中文名稱：
    半胱胺酸蛋白酶蛋白-6抗體
  • 英文名稱：
    Rabbit anti-Caspase-6 subunit p18 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN41482R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41482R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41482R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱Caspase-6 subunit p18
中文名稱半胱胺酸蛋白酶蛋白-6抗體
別    名Caspase-6; Caspase-6 p18; cleaved Caspase-6 p18; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN; caspase-6 isoform alpha precursor.  
研究領域細胞生物  神經生物學  信號轉導  細胞凋亡  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, Dog, Rabbit, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18/33kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Caspase-6 subunit p18:27-130/293 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

Subunit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.

Similarity:
Belongs to the peptidase C14A family.

SWISS:
P55212

Gene ID:
839

Database links:

Entrez Gene: 839 Human

Entrez Gene: 12368 Mouse

Entrez Gene: 83584 Rat

Omim: 601532 Human

SwissProt: P55212 Human

SwissProt: O08738 Mouse

SwissProt: O35397 Rat

Unigene: 654616 Human

Unigene: 281379 Mouse

Unigene: 88160 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Caspase-6 與Caspase-3有38%的同源性，屬胱氨酸-天冬氨酸蛋白酶家族。在凋亡執(zhí)行階段起中心作用，可被Caspase-7、-8、-10剪切。它是唯一一個可以剪切核纖層蛋白的Caspase。















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