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CD20抗體
  • 產(chǎn)品貨號(hào)：
    BN41480R
  • 中文名稱：
    CD20抗體
  • 英文名稱：
    Rabbit anti-CD20 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41480R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Rabbit) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN41480R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Rabbit) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN41480R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Rabbit) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱CD20
中文名稱CD20抗體
別    名CD20_HUMAN; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; MS4A1; MS4A2; B1; CVID5; LEU-16; S7.



研究領(lǐng)域腫瘤  免疫學(xué)  干細(xì)胞  細(xì)胞表面分子  細(xì)胞類型標(biāo)志物  淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD20:133-182/297 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹CD20 is a non glycosylated protein with a molecular weight of 35 or 37 kDa depending on the degree of phosphorylation. Although not a member of the tetraspanin superfamily of cell surface receptors, it crosses the cell membrane four times. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit.

Function:
This protein may be involved in the regulation of B-cell activation and proliferation

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed on B-cells.

Post-translational modifications:
Phosphorylated. Might be functionally regulated by protein kinase(s).

DISEASE:
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Similarity:
Belongs to the MS4A family.

SWISS:
P11836

Gene ID:
931

Database links:

Entrez Gene: 931 Human

Omim: 112210 Human

SwissProt: P11836 Human

Unigene: 712553 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

[PHARMACEUTICAL] Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity.

B淋巴細(xì)胞標(biāo)志物

CD20是B細(xì)胞特異性抗原，其表達(dá)呈細(xì)胞類型一種質(zhì)膜蛋白質(zhì)，參與信號(hào)傳導(dǎo)作用，此抗體識(shí)別大多數(shù)B細(xì)胞上的一種抗原。多用于標(biāo)記B淋巴細(xì)胞及B細(xì)胞淋巴瘤。
CD20一般不與T細(xì)胞交叉反應(yīng)，對(duì)B細(xì)胞淋巴瘤和急慢性淋巴細(xì)胞白血病等有較好的細(xì)胞特異性，因此在惡性淋巴瘤，尤其是T或B細(xì)胞淋巴瘤的分類上，CD20是最常用的B細(xì)胞標(biāo)志。