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鈣結(jié)合蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41476R
  • 中文名稱：
    鈣結(jié)合蛋白抗體
  • 英文名稱：
    Rabbit anti-Calretinin Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41476R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Human(predicted:Horse,Cow,Pig,Dog,Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41476R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Human(predicted:Horse,Cow,Pig,Dog,Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41476R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Human(predicted:Horse,Cow,Pig,Dog,Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Calretinin
中文名稱鈣結(jié)合蛋白抗體
別    名29 kDa calbindin; CAB 29; CAB29; CAL 2; CAL2; CALB 2; CALB2; Calbindin 2 29kDa; Calbindin 2; Calbindin D29K; Calbindin2; CR; CALB2_HUMAN; Calretinin.  
研究領(lǐng)域神經(jīng)生物學(xué)  結(jié)合蛋白  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Calretinin:211-271/271 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Calretinin is a calcium-binding protein which is abundant in auditory neurons. It belongs to the calbindin family. Calbindin 2 (calretinin), closely related to calbindin 1, is an intracellular calcium-binding protein belonging to the troponin C superfamily. Calbindin 1 is known to be involved in the vitamin-D-dependent calcium absorption through intestinal and renal epithelia, while the function of neuronal calbindin 1 and calbindin2 is poorly understood. The sequence of the calbindin 2 cDNA reveals an open reading frame of 271 codons coding for a protein of 31,520 Da, and shares 58% identical residues with human calbindin1.

Function:
Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Tissue Specificity:
Brain.

Similarity:
Belongs to the calbindin family.
Contains 6 EF-hand domains.

SWISS:
P22676

Gene ID:
794

Database links:

Entrez Gene: 396255 Chicken

Entrez Gene: 794 Human

Entrez Gene: 12308 Mouse

Entrez Gene: 117059 Rat

Entrez Gene: 393684 Zebrafish

Omim: 114051 Human

SwissProt: P07090 Chicken

SwissProt: P22676 Human

SwissProt: Q08331 Mouse

SwissProt: P47728 Rat

Unigene: 106857 Human

Unigene: 2755 Mouse

Unigene: 10321 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


鈣結(jié)合蛋白(Calretinin,CR)主要存在于神經(jīng)組織中，近10%的腺癌可以表達(dá)此蛋白的局部染色陽(yáng)性，而絕大多數(shù)的間皮瘤為陽(yáng)性表達(dá)，因此它是診斷間皮瘤的一個(gè)有用的標(biāo)記物 。
鈣結(jié)合蛋白是平滑肌和非肌性調(diào)控蛋白。它可以與肌動(dòng)蛋白、肌球蛋白、原肌球蛋白和鈣調(diào)素相互作用。