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產(chǎn)品規(guī)格
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BN41475R-50ul
50ul
￥1486.00
交叉反應：Mouse,Rat(predicted:Human,Pig,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA
BN41475R-100ul
100ul
￥2360.00
交叉反應：Mouse,Rat(predicted:Human,Pig,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA
BN41475R-200ul
200ul
￥3490.00
交叉反應：Mouse,Rat(predicted:Human,Pig,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | Proinsulin |
| 中文名稱 | 胰島素原抗體 |
| 別 名 | INS_HUMAN; ILPR; INS; Insulin A chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor. |
| 研究領域 | 腫瘤 心血管 細胞生物 神經(jīng)生物學 信號轉導 生長因子和激素 糖尿病 內(nèi)分泌病 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 5.8/12kDa |
| 細胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Insulin:46-59/110 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Insulin is a pancreatic hormone that regulates glucose and is involved in the synthesis of protein and fat. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds.Belongs to the insulin family. The insulin-link growth factors, IGF-I and IGF-II (also desinated somatomedin C and multiplication stimulating activator, respectvely), share approximatly 76% sequence identity and are 50% related to pro-insulin.IGF-I and IGF-II are nonglycosylated, single chain proteins of 70 and 76 amino acids in length, respectivelly. IGF-I functions as an autocrine regulator of growth in vaious, whereas the function of IGF-II is less well defined. Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds. Subcellular Location: Secreted. DISEASE: Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730]. Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic dieresis and secondary thirst. These derangements result in long-term complications that Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Similarity: Belongs to the insulin family. SWISS: P01308 Gene ID: 3630 Database links: Entrez Gene: 3630 Human Entrez Gene: 16333 Mouse Entrez Gene: 16334 Mouse Omim: 176730 Human SwissProt: P01308 Human SwissProt: P01325 Mouse Unigene: 272259 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰島素（Isulin）胰島素抗體是胰島細胞分泌得一種激素，可以減底血糖濃度。此抗體和人胰島素反應，并與大多數(shù)哺乳類動物的胰島素有交叉反應，主要用于胰島細胞瘤的功能性研究。 |
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