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磷酸化原癌基因蛋白18抗體
  • 產品貨號：
    BN41405R
  • 中文名稱：
    磷酸化原癌基因蛋白18抗體
  • 英文名稱：
    Rabbit anti-phospho-Stathmin 1 (Ser63) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41405R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Cow,Rabbit) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱phospho-Stathmin 1 (Ser63)
中文名稱磷酸化原癌基因蛋白18抗體
別    名Stathmin 1 (phospho S63); p-Stathmin 1 (phospho S63); Stathmin 1 (Phospho-Ser63); Stathmin (Phospho Ser63); Stathmin (Phospho S63); Lag; LAP 18; LAP18; Leukemia associated phosphoprotein p18; Metablastin; Oncoprotein 18; OP 18; OP18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; PP17; PP19; PR22; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin; Stathmin1; STMN 1; STMN1; STMN1_HUMAN.  
產品類型磷酸化抗體 
研究領域腫瘤  細胞生物  神經生物學  信號轉導  細胞粘附分子  細胞骨架  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Chicken, Cow, Rabbit, )
產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human Stathmin 1 around the phosphorylation site of Ser63:41-140/149 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Function:
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.

Subunit:
Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.

Subcellular Location:
Cytoplasm, cytoskeleton.

Tissue Specificity:
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Post-translational modifications:
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.

Similarity:
Belongs to the stathmin family.

SWISS:
P16949

Gene ID:
3925

Database links:

Entrez Gene: 3925 Human

Entrez Gene: 16765 Mouse

Entrez Gene: 29332 Rat

Omim: 151442 Human

SwissProt: P16949 Human

SwissProt: P54227 Mouse

SwissProt: P13668 Rat

Unigene: 209983 Human

Unigene: 378957 Mouse

Unigene: 555 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

原癌基因蛋白18(oncogene protein 18,Op18),是一種廣泛存在于細胞質的蛋白質,可與微管蛋白結合,參與微管和紡錘體的組裝;與細胞的增殖、分化、再生和運動均有關,并具有信號活性調節(jié)的功能。在細胞增殖、分化的信號途徑、傳到通路激活中也具有多種調節(jié)功能。
近年來有研究發(fā)現(xiàn),stathmin在多種腫瘤中高表達,并可通過調節(jié)微管的解聚,促進腫瘤細胞的運動及侵襲。Stathmin翻譯后修飾狀態(tài)的改變,可影響與p53蛋白的相互作用,參與腫瘤的發(fā)生發(fā)展.