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線粒體鈉/氫交換蛋白質2抗體
  • 產品貨號：
    BN41401R
  • 中文名稱：
    線粒體鈉/氫交換蛋白質2抗體
  • 英文名稱：
    Rabbit anti-NHEDC2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41401R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,ELISA

  • BN41401R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應用：WB,ELISA

產品描述

英文名稱NHEDC2
中文名稱線粒體鈉/氫交換蛋白質2抗體
別    名NHA2; Mitochondrial Na(+)/H(+) exchanger NHA2; Mitochondrial sodium/hydrogen exchanger NHA2; Na(+)/H(+) exchanger like domain containing protein 2; Na+/H+ exchanger domain containing 2; NHE domain containing protein 2; NHE10; NHEDC 2; Sodium/hydrogen exchanger like domain containing protein 2; SL9B2_HUMAN.  
研究領域細胞生物  信號轉導  細胞周期蛋白  細胞分化  細胞骨架  細胞外基質  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, Dog, Rabbit, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量58kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NHEDC2:151-250/537 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. NHEDC2 (Na+/H+ exchanger-like domain-containing protein 2), also known as NHA2, is a 537 amino acid mitochondrial protein. NHEDC2 is involved in organelle volume homeostasis by catalyzing the exchange of protons for Na+ and Li+ across the inner mitochondrial membrane. Found in red blood cells, NHEDC2 is required for bone resorption activity and osteoclast differentiation. As a multi-pass membrane protein, NHEDC2 is expressed as two isoforms produced by alternative splicing events.

Function:
Electroneutral exchange of protons for Na(+) and Li(+)across the inner mitochondrial membrane. Contributes to theorganellar volume homeostasis. Required for osteoclastdifferentiation and bone resorption activity (By similarity).

Subcellular Location:
Mitochondrion membrane; Multi-pass membraneprotein (By similarity).

Tissue Specificity:
Detected in red blood cells (at proteinlevel).

Similarity:
Belongs to the monovalent cation:proton antiporter 1(CPA1) transporter (TC 2.A.36) family.

SWISS:
Q86UD5

Gene ID:
133308

Database links:

Entrez Gene: 133308 Human

Entrez Gene: 97086 Mouse

Entrez Gene: 365946 Rat

Omim: 611789 Human

SwissProt: Q86UD5 Human

SwissProt: Q5BKR2 Mouse

Unigene: 546482 Human

Unigene: 441764 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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