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絲氨酸/蘇氨酸蛋白激酶TNN13K抗體
  • 產(chǎn)品貨號(hào)：
    BN41389R
  • 中文名稱：
    絲氨酸/蘇氨酸蛋白激酶TNN13K抗體
  • 英文名稱：
    Rabbit anti-TNNI3K Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41389R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41389R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱TNNI3K
中文名稱絲氨酸/蘇氨酸蛋白激酶TNN13K抗體
別    名Cardiac ankyrin repeat kinase; CARK; MGC142099; MGC33828; Serine/threonine protein kinase TNN13K; Serine/threonine-protein kinase TNNI3K; TNI3K_HUMAN; TNNI3 interacting kinase; TNNI3-interacting kinase; Tnni3k.  
研究領(lǐng)域腫瘤  心血管  免疫學(xué)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Chicken, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量93kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TNNI3K:1-100/835 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹TNNI3K, also known as CARK, is a 936 amino acid serine/threonine-protein kinase that is highly expressed in heart. Overexpression of TNNI3K leads to improved cardiac function by enhancing beating frequency and increasing contractile force and epinephrine response. TNNI3K suppresses phosphorylation of cardiac troponin I and p38/JNK-mediated apoptosis, therefore protecting the myocardium from ischemic injury. Administration of TNNI3K to mice with myocardial infarction improves cardiac performance and attentuates ventricular remodeling, suggesting that TNNI3K could be a promising target in the treatment of cardiac diseases. There are four isoforms of TNNI3K that are produced as a result of alternative splicing events.

Function:
May play a role in cardiac physiology.

Subunit:
Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.

Subcellular Location:
Nucleus. Cytoplasm. Expressed at lower levels in the cytoplasm.

Tissue Specificity:
Highly expressed in both adult and fetal heart.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 10 ANK repeats.
Contains 1 protein kinase domain.

SWISS:
Q59H18

Gene ID:
51086

Database links:

Entrez Gene: 51086 Human

Entrez Gene: 435766 Mouse

Entrez Gene: 295531 Rat

SwissProt: Q59H18 Human

SwissProt: Q5GIG6 Mouse

SwissProt: Q7TQP6 Rat

Unigene: 729320 Human

Unigene: 210428 Mouse

Unigene: 3434 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.