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多胺調控因子1抗體
  • 產品貨號：
    BN41378R
  • 中文名稱：
    多胺調控因子1抗體
  • 英文名稱：
    Rabbit anti-NNF1R Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41378R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,ELISA

  • BN41378R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,ELISA

產品描述

英文名稱NNF1R
中文名稱多胺調控因子1抗體
別    名PMF-1; Pmf1; PMF1_HUMAN; NNF1R; Polyamine modulated factor 1; Polyamine-modulated factor 1.  
研究領域細胞生物  信號轉導  細胞周期蛋白  細胞分化  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Sheep, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NNF1R/PMF1:101-200/300 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹NNF1R, also called PMF1, is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. It is required for chromosome congression and for correct operation of the spindle checkpoint. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.

Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.

Subunit:
Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU.

Subcellular Location:
Nucleus. Associated with the kinetochore.

SWISS:
Q6P1K2

Gene ID:
11243

Database links:

Entrez Gene: 100527963 Human

Entrez Gene: 11243 Human

Entrez Gene: 67037 Mouse

Entrez Gene: 681050 Rat

Omim: 609176 Human

SwissProt: Q6P1K2 Human

SwissProt: Q9CPV5 Mouse

Unigene: 530479 Human

Unigene: 654541 Human

Unigene: 36715 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.












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