最近搜索：細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁>>免疫學(xué)>>一抗>>G蛋白通路抑制蛋白1抗體
G蛋白通路抑制蛋白1抗體
  • 產(chǎn)品貨號：
    BN41367R
  • 中文名稱：
    G蛋白通路抑制蛋白1抗體
  • 英文名稱：
    Rabbit anti-GPS1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41367R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Cow) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41367R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Cow) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱GPS1
中文名稱G蛋白通路抑制蛋白1抗體
別    名Arabidopsis Fus6/Cop 11 homolog; Arabidopsis Fus6/Cop 11 homolog; constitutive photomorphogenic homolog subunit 1; constitutive photomorphogenic homolog subunit 1; COP9; COP9 signalosome complex subunit 1; COP9 signalosome complex subunit 1; COPS1; COPS1; CSN 1; CSN1_HUMAN; G protein pathway suppressor 1; G protein pathway suppressor 1; GPS-1; GPS1; GPS1; JAB1-containing signalosome subunit 1; MFH protein; MFH protein; Protein GPS1; Protein MFH; SGN1; Signalosome subunit 1; Y59A8A.1.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  激酶和磷酸酶  G蛋白信號  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GPS1/CSN1:301-400/491 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.

Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.

Subunit:
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and CSN5. Interacts directly with inositol kinase ITPK1. Interacts with CAPN8 (By similarity).

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the CSN1 family.
Contains 1 PCI domain.

SWISS:
Q13098

Gene ID:
2873

Database links:

Entrez Gene: 2873 Human

Entrez Gene: 209318 Mouse

Entrez Gene: 117039 Rat

Omim: 601934 Human

SwissProt: Q13098 Human

SwissProt: Q99LD4 Mouse

SwissProt: P97834 Rat

Unigene: 268530 Human

Unigene: 30195 Mouse

Unigene: 16873 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.