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吡哆醛激酶抗體
  • 產(chǎn)品貨號：
    BN41359R
  • 中文名稱：
    吡哆醛激酶抗體
  • 英文名稱：
    Rabbit anti-PDXK Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41359R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat,Dog,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41359R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Mouse,Rat,Dog,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱PDXK
中文名稱吡哆醛激酶抗體
別    名PDXK.1; PDXK_HUMAN; PKH; PNK; Pyridoxal kinase; Pyridoxamine kinase; Pyridoxine kinase; Vitamin B6 kinase.  
研究領域細胞生物  信號轉導  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, Dog, Horse, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PDXK:101-200/312 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Pyridoxal kinase belongs to the pyridoxine kinase family and phosphorylates vitamin B6, a step necessary for the conversion of vitamin B6 to pyridoxal 5’ phosphate (PLP), the active form of vitamin B6. PLP acts as a coenzyme and functions to maintain homeostasis. Pyridoxal kinase is a 312-amino acid cytoplasmic protein that may act as a homodimer and is expressed ubiquitously. There are three known isoforms of pyridoxal kinase, and isoform 3 expression is observed in adult testis and spermatozoa. The optimum pH for pyridoxal kinase is between 5.5 and 6.0. PDXK, the gene that encodes the pyridoxal kinase protein, maps to chromosome 21q22.3 and may be a candidate gene for autoimmune polyglandular disease type 1, a genetic disorder that has been mapped to the same region on chromosome 21.

Function:
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.

Subunit:
Homodimer (Probable).

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitous. Isoform 3 is detected in adult testis and spermatozoa.

Similarity:
Belongs to the pyridoxine kinase family.

SWISS:
O00764

Gene ID:
8566

Database links:

Entrez Gene: 8566 Human

Entrez Gene: 216134 Mouse

Omim: 179020 Human

SwissProt: O00764 Human

SwissProt: Q8K183 Mouse

Unigene: 284491 Human

Unigene: 206159 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications