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電壓門(mén)控鉀通道蛋白1抗體
  • 產(chǎn)品貨號(hào)：
    BN41346R
  • 中文名稱(chēng)：
    電壓門(mén)控鉀通道蛋白1抗體
  • 英文名稱(chēng)：
    Rabbit anti-KCNAB1/Kv beta 1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

    產(chǎn)品規(guī)格

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  • BN41346R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN41346R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱(chēng)KCNAB1/Kv beta 1
中文名稱(chēng)電壓門(mén)控鉀通道蛋白1抗體
別    名hKvb3; hKvBeta3; K(+) channel subunit beta-1; KCAB1_HUMAN; KCNA1B; KCNAB1; KV-BETA-1; Kvb1.3; Voltage-gated potassium channel beta-1 subunit; Voltage-gated potassium channel subunit beta-1.  
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  通道蛋白  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KCNAB1/Kv beta 1:131-230/419 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming ? subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV∫, also known as KCNAB1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1), is a 419 amino acid accessory K+ channel protein that exists as three alternatively spliced isoforms and regulates the activity of the pore-forming ? subunit. It is expressed in brain, with highest levels detected in caudate nucleus, hippocampus and thalamus.

Function:
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.

Subunit:
Forms heteromultimeric complex with alpha subunits. Interacts with SQSTM1 (By similarity). Part of a complex containing KCNA1, KCNA4 and LGI1 (By similarity).

Subcellular Location:
Cytoplasm.

Tissue Specificity:
In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.

Similarity:
Belongs to the shaker potassium channel beta subunit family.

SWISS:
Q14722

Gene ID:
7881

Database links:

Entrez Gene: 395730 Chicken

Entrez Gene: 526133 Cow

Entrez Gene: 7881 Human

Entrez Gene: 16497 Mouse

Entrez Gene: 100125830 Pig

Entrez Gene: 29737 Rat

GenBank: NP_751891 Human

Omim: 601141 Human

SwissProt: Q9PWR1 Chicken

SwissProt: Q4PJK1 Cow

SwissProt: Q14722 Human

SwissProt: P63143 Mouse

SwissProt: P63144 Rat

Unigene: 654519 Human

Unigene: 703187 Human

Unigene: 316402 Mouse

Unigene: 32090 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.