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細(xì)胞骨架肌動(dòng)蛋白樣蛋白3抗體
  • 產(chǎn)品貨號(hào)：
    BN41248R
  • 中文名稱：
    細(xì)胞骨架肌動(dòng)蛋白樣蛋白3抗體
  • 英文名稱：
    Rabbit anti-ARP3 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41248R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：ICC,IF,ELISA

  • BN41248R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：ICC,IF,ELISA

產(chǎn)品描述

英文名稱ARP3
中文名稱細(xì)胞骨架肌動(dòng)蛋白樣蛋白3抗體
別    名Actin-like protein 3; Actin-related protein 3; ACTR3; ARP3 actin-related protein 3 homolog; ARP3_HUMAN.  
研究領(lǐng)域細(xì)胞生物  細(xì)胞粘附分子  細(xì)胞骨架  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 ICC=1:100-500 IF=1:100-500 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ARP3:301-400/418 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Actin polymerization is required for a variety of cell functions, including chemotaxis, cell migration, cell adhesion, and platelet activation. Cells trigger actin polymerization through either the de novo nucleation of filaments from monomeric actin, the severing of existing filaments to create uncapped barbed ends, or the uncapping existing barbed ends. The nucleation of actin is a rate-limiting and unfavorable reaction in actin polymerization and therefore requires the involvement of the Arp2/3 complex, which helps create new filaments and promotes the end-to-side cross-linking of actin filaments into the branching meshwork. The Arp2/3 complex consists of the actin-related proteins Arp2 and Arp3, and various other accessory proteins. The Arp2/3 complex promotes actin nucleation by binding the pointed end of actin filaments, or by associating with the side of an existing filament, and nucleates growth in the barbed direction. In addition, the Arp2/3 complex also mediates actin cytoskeletal outgrowths that are regulated by the Rho family of small GTPases. In response to GTP-binding Cdc42, the Arp2/3 complex binds the Cdc42 substrates, namely the WASP proteins, and initiates the formation of lamellipodia and filopodia.

Function:
The Arp2/3 complex involved in Golgi polerization in NIH3T3 cells. In a different model it has been shown that the Arp2/3 complex is necessary for neutrophil chemotaxis and phagocytosis.

Subunit:
Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell projection.

Similarity:
Belongs to the actin family. ARP3 subfamily.

SWISS:
P61158

Gene ID:
10096

Database links:

Entrez Gene: 10096 Human

Omim: 604222 Human

SwissProt: P61158 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.