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死亡效應(yīng)結(jié)構(gòu)域蛋白1抗體
  • 產(chǎn)品貨號(hào)：
    BN41244R
  • 中文名稱：
    死亡效應(yīng)結(jié)構(gòu)域蛋白1抗體
  • 英文名稱：
    Rabbit anti-DEDD1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41244R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41244R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱DEDD1
中文名稱死亡效應(yīng)結(jié)構(gòu)域蛋白1抗體
別    名CASP8IP1; Death effector domain containing; Death effector domain containing protein; Death effector domain containing testicular molecule; DEDD 1; DEDD1; DEDPro 1; DEDPro1; DEFT; FLDED 1; FLDED1; KE 05; KE05; OTTHUMP00000031822.  
研究領(lǐng)域腫瘤  細(xì)胞生物  細(xì)胞凋亡  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Chicken, Pig, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human DEDD1:151-250/318 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.

Function:
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.

Subunit:
Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.

Subcellular Location:
Cytoplasm. Nucleus, nucleolus.

Tissue Specificity:
Widely expressed with highest levels in testis.

Post-translational modifications:
Exists predominantly in a mono- or diubiquitinated form.

Similarity:
Contains 1 DED (death effector) domain.

SWISS:
O75618

Gene ID:
9191

Database links:

Entrez Gene: 9191 Human

Entrez Gene: 21945 Mouse

Entrez Gene: 83631 Rat

Omim: 606841 Human

SwissProt: O75618 Human

SwissProt: Q9Z1L3 Mouse

SwissProt: Q9Z2K0 Rat

Unigene: 146406 Human

Unigene: 270139 Mouse

Unigene: 203286 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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