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絲裂原活化蛋白激酶組織蛋白1抗體
  • 產品貨號：
    BN41229R
  • 中文名稱：
    絲裂原活化蛋白激酶組織蛋白1抗體
  • 英文名稱：
    Rabbit anti-MAPK organizer 1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41229R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41229R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱MAPK organizer 1
中文名稱絲裂原活化蛋白激酶組織蛋白1抗體
別    名MAPK organizer 1; MGC4238; Mitogen activated protein kinase organizer 1; Mitogen-activated protein kinase organizer 1; MORG 1; WD repeat domain-containing protein 83; wdr83; WDR83_HUMAN.  
研究領域心血管  細胞生物  信號轉導  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MAPK organizer 1:201-315/315 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Function:
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.

Subunit:
Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1. Identified in the spliceosome C complex.

Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.

Similarity:
Belongs to the WD repeat MORG1 family.
Contains 7 WD repeats.

SWISS:
Q9BRX9

Gene ID:
84292

Database links:

Entrez Gene: 84292 Human

Entrez Gene: 67836 Mouse

Entrez Gene: 288924 Rat

SwissProt: Q9BRX9 Human

SwissProt: Q9DAJ4 Mouse

SwissProt: Q5BLX8 Rat

Unigene: 657204 Human

Unigene: 334680 Mouse

Unigene: 3570 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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