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G蛋白α亞單位蛋白Q抗體
  • 產(chǎn)品貨號：
    BN41193R
  • 中文名稱：
    G蛋白α亞單位蛋白Q抗體
  • 英文名稱：
    Rabbit anti-GNAQ Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41193R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,ELISA

  • BN41193R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱GNAQ
中文名稱G蛋白α亞單位蛋白Q抗體
別    名G ALPHA q; G protein alpha Q; GAQ; Guanine nucleotide binding protein alpha q; Guanine nucleotide binding protein G q subunit alpha; GNAQ_HUMAN.  
研究領(lǐng)域腫瘤  心血管  細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
細胞定位細胞核 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GNAQ:51-150/359 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹GNAQ belong to the family of heterotrimeric Guanine nucleotide-binding proteins proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. GNAQ is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta. in recent studies over expression of GNAQ is associated with cardiomyocyte apoptosis.

Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).

Subunit:
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Binds SLC9A3R1. Forms a complex with PECAM1 and BDKRB2. Interacts with PECAM1.

Subcellular Location:
Nucleus (By similarity). Membrane (By similarity). Nucleus membrane (By similarity). Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity).

Tissue Specificity:
Predominantly expressed in ovary, prostate, testis and colon.

Similarity:
Belongs to the G-alpha family. G(q) subfamily.

SWISS:
P50148

Gene ID:
2776

Database links:

Entrez Gene: 2776 Human

Entrez Gene: 14682 Mouse

Entrez Gene: 654405 Pig

Entrez Gene: 81666 Rat

Omim: 600998 Human

SwissProt: P50148 Human

SwissProt: P21279 Mouse

SwissProt: Q2PKF4 Pig

SwissProt: P82471 Rat

Unigene: 269782 Human

Unigene: 439701 Mouse

Unigene: 441601 Mouse

Unigene: 22817 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Gαq是G蛋白家族成員之一,是Gq蛋白的功能單位。其功能為傳導(dǎo)來自GPCR的信號到細胞內(nèi)。研究證明,Gαq與免疫細胞活化、增殖、死亡、分化、遷移,細胞因子分泌以及自身免疫等均有非常密切的關(guān)系。