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Ras-GTP酶激活蛋白3抗體
  • 產(chǎn)品貨號：
    BN41181R
  • 中文名稱：
    Ras-GTP酶激活蛋白3抗體
  • 英文名稱：
    Rabbit anti-RASA3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41181R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse) 推薦應用：WB,ELISA

  • BN41181R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱RASA3
中文名稱Ras-GTP酶激活蛋白3抗體
別    名GAP III; GAP1(IP4BP); GAP1IP4BP; GAPIII; GTPase activating protein III; Inositol 1 3 4 5 tetrakisphosphate binding protein; Inositol 1345 tetrakisphosphate binding protein; Ins P4 binding protein; Ins(1 3 4 5)P4 binding protein; Ins(1345)P4 binding protein; Ras GTPase activating protein 3; RAS p21 protein activator 3; RASA 3.RASA3_HUMAN  
研究領(lǐng)域免疫學  信號轉(zhuǎn)導  G蛋白偶聯(lián)受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量91kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human RASA3:501-600/834 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹RASA3 is a inhibitory regulator of the Ras-cyclic AMP pathway and is a member of the GAP1 family of GTPase-activating proteins. It stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. RASA3 is an inositol 1,3,4,5-tetrakisphosphate-binding protein (IP4).

Function:
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.

Subcellular Location:
Cell membrane.

Similarity:
Contains 1 Btk-type zinc finger.
Contains 2 C2 domains.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.

SWISS:
Q14644

Gene ID:
22821

Database links:

Entrez Gene: 22821 Human

Entrez Gene: 19414 Mouse

Entrez Gene: 29372 Rat

Omim: 605182 Human

SwissProt: Q14644 Human

SwissProt: Q60790 Mouse

SwissProt: Q9QYJ2 Rat

Unigene: 593075 Human

Unigene: 18517 Mouse

Unigene: 224604 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.