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癌細胞高表達蛋白Hec1抗體
  • 產品貨號：
    BN41165R
  • 中文名稱：
    癌細胞高表達蛋白Hec1抗體
  • 英文名稱：
    Rabbit anti-HEC1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41165R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,ELISA

  • BN41165R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,ELISA

產品描述

英文名稱HEC1
中文名稱癌細胞高表達蛋白Hec1抗體
別    名HEC 1; HEC; Highly Expressed in Cancer; Highly expressed in cancer protein; Highly expressed in cancer rich in leucine heptad repeats; HsHec1; hsNDC80; Kinetochore Associated 2; Kinetochore associated protein 2; Kinetochore protein Hec1; Kinetochore protein NDC80 homolog; Kinetochore-associated protein 2; KNTC 2; KNTC2; NDC 80; NDC80; NDC80_HUMAN; Retinoblastoma associated protein HEC; Retinoblastoma-associated protein HEC.  
研究領域腫瘤  細胞生物  免疫學  細胞周期蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量74kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HEC1:21-120/642 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Function:
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

Subunit:
Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end. Interacts with isoform 1 of NEK2 and ZWINT specifically during mitosis. Interacts with CENPH and MIS12. May interact with AURKB, PSMC2, PSMC5 and SMC1A. May interact with RB1 during G2 phase and mitosis.

Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore.

Post-translational modifications:
Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.

Similarity:
Belongs to the NDC80/HEC1 family.

SWISS:
O14777

Gene ID:
10403

Database links:

Entrez Gene: 10403 Human

Entrez Gene: 67052 Mouse

Omim: 607272 Human

SwissProt: O14777 Human

SwissProt: Q9D0F1 Mouse

Unigene: 414407 Human

Unigene: 225956 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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