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磷酸化成骨特異性轉(zhuǎn)錄因子抗體
  • 產(chǎn)品貨號：
    BN41160R
  • 中文名稱：
    磷酸化成骨特異性轉(zhuǎn)錄因子抗體
  • 英文名稱：
    Rabbit anti-phospho-RUNX2 (Ser451) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41160R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human(predicted:Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱phospho-RUNX2 (Ser451)
中文名稱磷酸化成骨特異性轉(zhuǎn)錄因子抗體
別    名RUNX2(phospho S451); Runt-related Transcription Factor 2; CBF alpha 1; CBFA1; CCD; CCD1; Cleidocranial dysplasia 1; Core binding factor; Core binding factor runt domain alpha subunit 1; Core binding factor subunit alpha 1; MGC120023; Oncogene AML 3; OSF 2; OSF2; Osteoblast specific transcription factor 2; OTTHUMP00000016533; PEA2 alpha A; PEA2aA; PEBP2 alpha A; PEBP2A1; PEBP2A2; PEBP2aA1; Polyomavirus enhancer binding protein 2 alpha A subunit; Runt domain; Runt related transcription factor 2; SL3 3 enhancer factor 1 alpha A subunit; SL3/AKV core binding factor alpha A subunit.  




產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域免疫學(xué)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量67kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human RUNX2 around the phosphorylation site of Ser451:TS(p-S)GS 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.

Subunit:
Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with G22P1 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4.

Subcellular Location:
Nucleus.

Tissue Specificity:
Specifically expressed in osteoblasts.

Similarity:
Contains 1 Runt domain.

SWISS:
Q13950

Gene ID:
860

Database links:

Entrez Gene: 860 Human

Entrez Gene: 12393 Mouse

Entrez Gene: 100155806 Pig

Entrez Gene: 367218 Rat

Omim: 600211 Human

SwissProt: Q13950 Human

SwissProt: Q9XSB7 Horse

SwissProt: Q08775 Mouse

SwissProt: Q9Z2J9 Rat

Unigene: 535845 Human

Unigene: 391013 Mouse

Unigene: 391017 Mouse

Unigene: 214214 Rat

Unigene: 83672 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

RUNX2又稱：Cbfα1(Core-binding factor, alpha 3 subunit) 是新發(fā)現(xiàn)的一類調(diào)控間充質(zhì)干細(xì)胞向成骨方向分化的特異性轉(zhuǎn)錄因子,參與骨形成,骨骼生長和發(fā)育的一類重要細(xì)胞,它起源于多能間充質(zhì)干細(xì)胞,是間














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