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磷酸化肌細胞特異性增強因子2D抗體
  • 產品貨號：
    BN41107R
  • 中文名稱：
    磷酸化肌細胞特異性增強因子2D抗體
  • 英文名稱：
    Rabbit anti-phospho-MEF2D (Ser444) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41107R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱phospho-MEF2D (Ser444)
中文名稱磷酸化肌細胞特異性增強因子2D抗體
別    名MEF2D (phospho S444); p-MEF2D (phospho S444); MEF2D(phospho Ser444); DKFZp686I1536; MADS box transcription factor 2 polypeptide D; Mef2d; MEF2D_HUMAN; myocyte enhancer factor 2D; Myocyte specific enhancer factor 2, polypeptide D; Myocyte specific enhancer factor 2D; myocyte-specific enhancer factor 2D.   
產品類型磷酸化抗體 
研究領域心血管  免疫學  發(fā)育生物學  染色質和核信號  神經生物學  信號轉導  轉錄調節(jié)因子  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Rabbit, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human MEF2D around the phosphorylation site of Ser444:PV(p-S)PS 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹MEF2D is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants.

Function:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).

Subunit:
Forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells); the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A.

Subcellular Location:
Nucleus. Note=Translocated by HDAC4 to nuclear dots.

Post-translational modifications:
Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phosphorylation on Ser-180 can be enhanced by EGF. Phosphorylated and activated by CaMK4.
Acetylated on Lys-439 by CREBBP. Deacetylated by SIRT1.
Sumoylated on Lys-439 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3.
Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity).

Similarity:
Belongs to the MEF2 family.
Contains 1 MADS-box domain.
Contains 1 Mef2-type DNA-binding domain.

SWISS:
Q14814

Gene ID:
4209

Database links:

Entrez Gene: 4209 Human

Entrez Gene: 17261 Mouse

Entrez Gene: 81518 Rat

Omim: 600663 Human

SwissProt: Q14814 Human

SwissProt: Q63943 Mouse

SwissProt: O89038 Rat

Unigene: 314327 Human

Unigene: 28184 Mouse

Unigene: 89018 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MEF2D及其家族中的其他成員，在細胞存活、分化起著重要的作用。






















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