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錯配修復蛋白3抗體
  • 產品貨號：
    BN41027R
  • 中文名稱：
    錯配修復蛋白3抗體
  • 英文名稱：
    Rabbit anti-MSH3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41027R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F

  • BN41027R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F

產品描述

英文名稱MSH3
中文名稱錯配修復蛋白3抗體
別    名Divergent upstream protein; DNA mismatch repair protein; DNA mismatch repair protein Msh 3; DNA mismatch repair protein Msh3; DUC 1; DUC1; DUG; DUP; hMSH3; MGC163306; MGC163308; Mismatch repair protein 1; MRP 1; MRP1; MSH 3; MSH3; MSH3_HUMAN; MutS homolog 3 (E. coli); MutS homolog 3.  
研究領域細胞生物  免疫學  染色質和核信號  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, Rabbit, )
產品應用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量127kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MSH3:521-620/1137 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Function:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Subunit:
Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Defects in MSH3 are a cause of susceptibility to endometrial cancer (ENDMC) [MIM:608089].

Similarity:
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

SWISS:
P20585

Gene ID:
4437

Database links:

Entrez Gene: 4437 Human

Entrez Gene: 17686 Mouse

Omim: 600887 Human

SwissProt: P20585 Human

SwissProt: P13705 Mouse

Unigene: 280987 Human

Unigene: 343101 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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