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磷酸化p21激活激酶1抗體
  • 產(chǎn)品貨號：
    BN41011R
  • 中文名稱：
    磷酸化p21激活激酶1抗體
  • 英文名稱：
    Rabbit anti-phospho-PAK1 (Ser204) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41011R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱phospho-PAK1 (Ser204)
中文名稱磷酸化p21激活激酶1抗體
別    名PAK1 (phospho S204); p-PAK1 (phospho S204); ADRB2; Alpha PAK; Alpha-PAK; MGC130000; MGC130001; p21 activated kinase 1; p21 protein (Cdc42/Rac) activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p65 PAK; p65-PAK; P68-PAK; PAK alpha; PAK-1; Pak1; PAK1_HUMAN; Paka; PAKalpha; Protein kinase MUK2; Rac/p21-activated kinase; Serine/threonine-protein kinase PAK 1; STE20 homolog yeast.  
產(chǎn)品類型磷酸化抗體 
研究領域腫瘤  細胞生物  信號轉(zhuǎn)導  細胞凋亡  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, 
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量61kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human PAK1 around the phosphorylation site of Ser204:TR(p-S)VI 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Function:
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Subcellular Location:
Cytoplasm. Cell junction > focal adhesion. Recruited to focal adhesions upon activation.

Post-translational modifications:
Autophosphorylated when activated by CDC42/p21 and RAC1.

Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 CRIB domain.
Contains 1 protein kinase domain.

SWISS:
Q13153

Gene ID:
5058

Database links:

Entrez Gene: 5058 Human

Entrez Gene: 18479 Mouse

Entrez Gene: 29431 Rat

Omim: 602590 Human

SwissProt: Q13153 Human

SwissProt: O88643 Mouse

SwissProt: P35465 Rat

Unigene: 435714 Human

Unigene: 260227 Mouse

Unigene: 9149 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications















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