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腺苷酸環(huán)化酶1抗體
  • 產品貨號：
    BN40943R
  • 中文名稱：
    腺苷酸環(huán)化酶1抗體
  • 英文名稱：
    Rabbit anti-Adenylate cyclase 1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40943R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Rat(predicted:Mouse) 推薦應用：WB,IHC-P,ELISA

  • BN40943R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Rat(predicted:Mouse) 推薦應用：WB,IHC-P,ELISA

產品描述

英文名稱Adenylate cyclase 1
中文名稱腺苷酸環(huán)化酶1抗體
別    名3'5' cyclic AMP synthetase; ADCY1; adenyl cyclase; adenylate cyclase type I; ATP pyrophosphate lyase; Brain adenylate cyclase 1; Ca(2+)/calmodulin activated adenylyl cyclase; EC 4.6.1.1; ADCY1_HUMAN; Adenylate cyclase type 1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase. .  
研究領域腫瘤  細胞生物  免疫學  神經生物學  信號轉導  轉錄調節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量123kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human adenylate cyclase type I:751-850/1119 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹The membrane bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein coupled receptors. Eight human AC isoforms (AC-1 through AC-4) have been identified up to now and genes for at least nine adenylate cyclase (AC-1-AC-9) have been cloned characterized and sequenced. This is a calmodulin-sensitive adenylyl cyclase which may be involved in regulatory processes in the central nervous system. It may play a role in neuronal plasticity, memory acquisition and learning and is expressed predominantly in the brain, retina and adrenal medulla.

Function:
This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Brain, retina and adrenal medulla.

Similarity:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains.

SWISS:
Q08828

Gene ID:
107

Database links:

Entrez Gene: 107 Human

Entrez Gene: 432530 Mouse

Omim: 103072 Human

SwissProt: Q08828 Human

SwissProt: O88444 Mouse

Unigene: 192215 Human

Unigene: 259733 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

腺苷酸環(huán)化酶(adenylate cyclase, AC) 是G蛋白偶聯(lián)受體家族之一，是膜整合蛋白,它的氨基端和羧基端都朝向細胞質。AC在膜的細胞質面有兩個催化結構域,還有兩個膜整合區(qū),每個膜整合區(qū)分別有6個跨膜的α螺旋。哺乳動物中已發(fā)現(xiàn)6個腺苷酸環(huán)化酶異構體。由于AC能夠將ATP轉變成cAMP,引起細胞的信號應答,因此,腺苷酸環(huán)化酶是G蛋白偶聯(lián)系統(tǒng)中的效應