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磷酸化親環(huán)蛋白（親環(huán)素）PPIG抗體
  • 產(chǎn)品貨號(hào)：
    BN40925R
  • 中文名稱：
    磷酸化親環(huán)蛋白（親環(huán)素）PPIG抗體
  • 英文名稱：
    Rabbit anti-Phospho-PPIG (Ser376) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40925R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Phospho-PPIG (Ser376)
中文名稱磷酸化親環(huán)蛋白（親環(huán)素）PPIG抗體
別    名CARS cyclophilin; CARS Cyp; CASP 10; CASP10; Clk associating RS cyclophilin; Cyclophilin G; CyclophilinG; CYP; MGC133241; Peptidyl prolyl cis trans isomerase G; Peptidyl prolyl isomerase G; Peptidylprolyl isomerase G (cyclophilin G); Peptidylprolyl isomerase G; PPIase G; Rotamase G; RotamaseG; PPIG_HUMAN.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量89kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human PPIG around the phosphorylation site of Ser376:VS(p-S)GE 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹PPIG belongs to the the peptidyl-prolyl cis/trans isomerase protein family (PPIases). PPIases accelerate the folding of proteins. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is implicated in the folding, transport, and assembly of proteins. It is distributed in nuclear speckles, a nuclear compartment rich in splicing factors, and colocalizes with the splicing factors SC35 and pinin, suggesting a role in the regulation of pre-mRNA splicing.

Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

Subunit:
Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.

Subcellular Location:
Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 PPIase cyclophilin-type domain.

SWISS:
Q13427

Gene ID:
9360

Database links:

Entrez Gene: 9360 Human

Entrez Gene: 228005 Mouse

Entrez Gene: 83624 Rat

Omim: 606093 Human

SwissProt: Q13427 Human

SwissProt: A2AR02 Mouse

SwissProt: O55035 Rat

Unigene: 727580 Human

Unigene: 11815 Mouse

Unigene: 474951 Mouse

Unigene: 10898 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肽基脯氨?；?lè)串悩?gòu)酶，廣泛存在于各種組織和器官。根據(jù)對(duì)免疫抑制劑的敏感性，分屬三個(gè)獨(dú)立的家族：親環(huán)蛋白PPIG、FK506結(jié)合蛋白和細(xì)蛋白。能夠加速自身折疊和體內(nèi)新生肽鏈折疊及變性蛋白質(zhì)的體外折疊，主要分布于內(nèi)質(zhì)網(wǎng)。


















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