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單核細(xì)胞趨化蛋白1抗體
  • 產(chǎn)品貨號(hào)：
    BN40911R
  • 中文名稱：
    單核細(xì)胞趨化蛋白1抗體
  • 英文名稱：
    Rabbit anti-MCP1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40911R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱MCP1
中文名稱單核細(xì)胞趨化蛋白1抗體
別    名MCP-1; monocyte chemotactic protein 1; CCL 2; CCL2; Chemokine C C motif ligand 2; Chemokine CC Motif Ligand 2; GDCF 2; GDCF 2 HC11; GDCF2; HC11; HSMCR30; JE; MCAF; MCP 1; MGC9434; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; Small inducible cytokine A2; Small inducible cytokine subfamily A Cys Cys member 2; SMC CF; SMCCF.  
研究領(lǐng)域腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量11kDa
細(xì)胞定位分泌型蛋白 
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MCP1: 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Processing at the N-terminus can regulate receptor and targetcell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility Belongs to the intercrine beta (chemokine CC) family. The MCP-1( the monocyte chemotactic protein1) has many pits that regulates the function toward sex to turn to record the factor, it can induce to have relation with inflammation with the immunity various genes turn to record.The immunity MCP-1 set turns the male signal to mainly locate the afterbirth syrup inside.

Function:
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

Subunit:
Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.

Subcellular Location:
Secreted.

Post-translational modifications:
Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

SWISS:
P13500

Gene ID:
6347

Database links:

Entrez Gene: 6347 Human

Entrez Gene: 20296 Mouse

Entrez Gene: 24770 Rat

Omim: 158105 Human

SwissProt: P13500 Human

SwissProt: P10148 Mouse

SwissProt: P14844 Rat

Unigene: 303649 Human

Unigene: 290320 Mouse

Unigene: 4772 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生長(zhǎng)因子和激素（ Growth Factor and Hormones） 巨噬細(xì)胞趨化蛋白1(MCP1)具有多向性調(diào)節(jié)作用的核轉(zhuǎn)錄因子，它可誘導(dǎo)與免疫和炎癥有關(guān)的多種基因轉(zhuǎn)錄.MCP-1免疫組化陽性信號(hào)主要位于胞漿內(nèi)。




















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