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磷酸化離子型谷氨酸受體1抗體
  • 產(chǎn)品貨號(hào)：
    BN40895R
  • 中文名稱：
    磷酸化離子型谷氨酸受體1抗體
  • 英文名稱：
    Rabbit anti-Phospho-NMDAR1 (Ser896) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40895R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Chicken,Dog,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Phospho-NMDAR1 (Ser896)
中文名稱磷酸化離子型谷氨酸受體1抗體
別    名NMDAR1 C1 (phospho S896); p-NMDAR1 C1 (phospho S896); NMDAR1(Phospho-Ser896); NMDAR1(Phospho-S896); NMDAR1 C1 (phospho S896); p-NMDAR1(S896); p-NMDAR1(Ser896); NMDA-NR1; N-Methyl-d-Asprtate receptor 1; GRIN1; NMDA1; NR1; Glutamate [NMDA] receptor subunit zeta 1; Glutamate receptor ionotropic N methyl D aspartate 1; Grin 1; Grin1; N methyl D aspartate receptor channel; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA 1; NMDA NR1; NMDA R1; NMDA receptor 1; NMDA1; NMDAR 1; NMDAR; NR 1; NMDZ1_HUMAN.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細(xì)胞類型標(biāo)志物  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量103kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human NMDAR1 around the phosphorylation site of Ser896:RR(p-S)SK <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.

Subunit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with MYZAP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Post-translational modifications:
NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.

DISEASE:
Defects in GRIN1 are the cause of mental retardation autosomal dominant type 8 (MRD8) [MIM:614254]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

Similarity:
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.

SWISS:
Q05586

Gene ID:
2902

Database links:

Entrez Gene: 2902 Human

Entrez Gene: 14810 Mouse

Entrez Gene: 24408 Rat

Omim: 138249 Human

SwissProt: Q05586 Human

SwissProt: P35438 Mouse

SwissProt: P35439 Rat

Unigene: 558334 Human

Unigene: 278672 Mouse

Unigene: 9840 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)細(xì)胞標(biāo)志物
(NMDAR1)N-甲基-D-天門冬氨酸受體(NMDAR)是興奮性氨基酸受體亞型之一，是由NMDAR1與不同的NMDAR2亞基組成的異聚體。
NMDAR1又稱GluR1 (Glutamate Receptor 1)近年實(shí)驗(yàn)研究發(fā)現(xiàn)，許多NMDAR拮抗藥均具有鎮(zhèn)痛活性，表明NMDAR在痛覺傳遞中具有重要作用，這為新型鎮(zhèn)痛藥的研究開發(fā)提供了新的作用靶點(diǎn)。


























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