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磷酸化微管相關蛋白2抗體
  • 產(chǎn)品貨號：
    BN40890R
  • 中文名稱：
    磷酸化微管相關蛋白2抗體
  • 英文名稱：
    Rabbit anti-Phospho-MAP2 (Ser136) Polyclonal antibody
  • 品牌：
    Biorigin

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    產(chǎn)品規(guī)格

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  • BN40890R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Rabbit) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Phospho-MAP2 (Ser136)
中文名稱磷酸化微管相關蛋白2抗體
別    名MAP2(Phospho Ser136); MAP2 (phospho S136); p-MAP2 (phospho S136); MAP2(Phospho S136); MAP2(Phospho-Ser136); p-MAP2(Phospho-Ser136); DKFZp686I2148; Dendrite specific MAP; DKFZp686I2148; MAP 2; MAP-2; MAP2; MAP2_HUMAN; MAP2A; MAP2B; MAP2C; Microtubule associated protein 2; Microtubule-associated protein 2; Mtap 2.  
產(chǎn)品類型磷酸化抗體 
研究領域免疫學  神經(jīng)生物學  信號轉導  干細胞  細胞凋亡  細胞類型標志物  細胞骨架  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2μg /Test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量70/201kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human MAP2 around the phosphorylation site of Ser136:PP(p-S)P 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.

Function:
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Subcellular Location:
Cytoplasm, cytoskeleton (Probable).

Post-translational modifications:
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated. Isoform MAP2c is phosphorylated by FYN at Tyr-67.

Similarity:
Contains 3 Tau/MAP repeats.

SWISS:
P11137

Gene ID:
4133

Database links:

Entrez Gene: 4133 Human

Entrez Gene: 17756 Mouse

Entrez Gene: 25595 Rat

Omim: 157130 Human

SwissProt: P11137 Human

SwissProt: P20357 Mouse

SwissProt: P15146 Rat

Unigene: 368281 Human

Unigene: 256966 Mouse

Unigene: 10484 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

微管相關蛋白 2（MAP-2)是一種磷蛋白質(zhì)，在正常腦組織中，主要存在于神經(jīng)元的胞體、樹突和樹突棘，是腦內(nèi)最豐富的蛋白之一。MAP-2在其調(diào)節(jié)微管的聚合作用和微管的穩(wěn)定性以及對神經(jīng)元軸突和樹突的發(fā)生、延長、穩(wěn)定和突觸可塑性調(diào)節(jié)具有重要作用。

















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