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磷酸化干擾素調(diào)節(jié)因子7抗體
  • 產(chǎn)品貨號：
    BN40875R
  • 中文名稱：
    磷酸化干擾素調(diào)節(jié)因子7抗體
  • 英文名稱：
    Rabbit anti-Phospho-IRF7 (Ser471 + Ser472) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40875R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Mouse,Rat(predicted:Pig,Cow,Horse) 推薦應用：WB,IHC-P,ICC,ELISA

產(chǎn)品描述

英文名稱Phospho-IRF7 (Ser471 + Ser472)
中文名稱磷酸化干擾素調(diào)節(jié)因子7抗體
別    名Interferon regulatory factor 7; Interferon regulatory factor 7H; IRF 7; IRF 7A; IRF 7H; IRF7A; IRF7; IRF7H.  


產(chǎn)品類型磷酸化抗體 
研究領域腫瘤  信號轉(zhuǎn)導  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Pig, Cow, Horse, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/test （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human IRF7 around the phosphorylation site of Ser471/472:GV(p-S)(p-S)LD 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]

Function:
Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.

Subunit:
Homodimer.

Subcellular Location:
Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.

Tissue Specificity:
Expressed predominantly in spleen, thymus and peripheral blood leukocytes.

Post-translational modifications:
In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.
TRAF6-mediated ubiquitination is required for IRF7 activation.

Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

SWISS:
Q92985

Gene ID:
3665

Database links:

Entrez Gene: 3665 Human

Entrez Gene: 54123 Mouse

Entrez Gene: 293624 Rat

Omim: 605047 Human

SwissProt: Q92985 Human

SwissProt: P70434 Mouse

Unigene: 166120 Human

Unigene: 3233 Mouse

Unigene: 101159 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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