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磷酸化鈣/鈣調(diào)素依賴蛋白激酶2α抗體
  • 產(chǎn)品貨號：
    BN40856R
  • 中文名稱：
    磷酸化鈣/鈣調(diào)素依賴蛋白激酶2α抗體
  • 英文名稱：
    Rabbit anti-phospho-CaMK2 alpha (Tyr230) Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40856R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱phospho-CaMK2 alpha (Tyr230)
中文名稱磷酸化鈣/鈣調(diào)素依賴蛋白激酶2α抗體
別    名phospho-CaMK2B (Tyr230); CaMK2B (phospho Tyr230); alpha CaMKII; CaMKII alpha; Calcium / Calmodulin Dependent Protein Kinase II G; Calcium calmodulin dependent protein kinase CaM kinase II alpha; Calcium calmodulin dependent protein kinase II alpha-B subunit; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II beta chain; CaM kinase II beta subunit; CaM kinase II delta chain; CaM kinase II delta subunit; CaM kinase II subunit alpha; CAM2; CaMK II alpha subunit; CaMK II beta subunit; CaMK II delta subunit; CaMK-II subunit alpha; CAMK2A; CAMK2B; CAMK2D; CAMKA; CAMKB; CaMKII; EC 2.7.11.17; KIAA0968; MGC123320; MGC139375; MGC155201; mKIAA0968; PK2CDD; PKCCD; R74975; zgc:112538; zgc:123320; KCC2A_HUMAN.  









產(chǎn)品類型磷酸化抗體 
研究領域細胞生物  免疫學  信號轉導  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human CaMK2 alpha around the phosphorylation site of Tyr231:GA(p-Y)DF 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Ca2+/CalmodulinDependent Protein Kinase II (CaM Kinase II) is a multifunctional calcium and calmodulindependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning.

Function:
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.

Subunit:
CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1.

Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.

SWISS:
Q9UQM7

Gene ID:
815

Database links:

Entrez Gene: 815 Human

Entrez Gene: 12322 Mouse

Entrez Gene: 25400 Rat

Omim: 114078 Human

SwissProt: Q9UQM7 Human

SwissProt: P11798 Mouse

SwissProt: P11275 Rat

Unigene: 725992 Human

Unigene: 131530 Mouse

Unigene: 107499 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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