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鋅指蛋白Aiolos抗體
  • 產(chǎn)品貨號(hào)：
    BN40838R
  • 中文名稱：
    鋅指蛋白Aiolos抗體
  • 英文名稱：
    Rabbit anti-IKZF3 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40838R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40838R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱IKZF3
中文名稱鋅指蛋白Aiolos抗體
別    名Aiolos; IKAROS family zinc finger 3 (Aiolos); IKAROS family zinc finger 3; Ikaros family zinc finger protein 3; IKZF 3; IKZF3; IKZF3_HUMAN; Zinc finger protein Aiolos; Zinc finger protein subfamily 1A 3 (Aiolos); Zinc finger protein subfamily 1A 3; ZNFN1A3.  
研究領(lǐng)域染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量58kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IKZF3 corresponding to amino acids:251-350/509 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹IKZF3 belongs to the Ikaros family of zinc-finger proteins. Members of this family are transcription factors that play an important role in the regulation of lymphocyte differentiation. They are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. IKZF3 is important in the regulation of B lymphocyte proliferation and differentiation.

Function:
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.

Subunit:
Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.

Post-translational modifications:
Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.

Similarity:
Belongs to the Ikaros C2H2-type zinc-finger protein family.
Contains 6 C2H2-type zinc fingers.

SWISS:
Q9UKT9

Gene ID:
22806

Database links:

Entrez Gene: 22806 Human

Entrez Gene: 22780 Mouse

Entrez Gene: 303511 Rat

Omim: 606221 Human

SwissProt: Q9UKT9 Human

SwissProt: O08900 Mouse

Unigene: 371680 Human

Unigene: 444388 Human

Unigene: 133367 Mouse

Unigene: 459157 Mouse

Unigene: 218596 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.