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瞬時受體電位離子通道蛋白/M亞家族抗體
  • 產品貨號：
    BN40835R
  • 中文名稱：
    瞬時受體電位離子通道蛋白/M亞家族抗體
  • 英文名稱：
    Rabbit anti-TRPM2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN40835R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat,Horse) 推薦應用：ELISA

  • BN40835R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Mouse,Rat,Horse) 推薦應用：ELISA

產品描述

英文名稱TRPM2
中文名稱瞬時受體電位離子通道蛋白/M亞家族抗體
別    名EREG 1; EREG1; TRPM2_HUMAN; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTRPC2; NUDT9H; NUDT9L1; putative Ca2+ channel protein; transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; TRPC 7; TRPC7.  
研究領域免疫學  神經生物學  通道蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, Horse, )
產品應用WB=1:500-2000 ELISA=1:2000-5000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量165kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TRPM2:951-1050/1503 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death.

Subunit:
Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
Contains 1 nudix hydrolase domain.

SWISS:
O94759

Gene ID:
7226

Database links:

Entrez Gene: 7226 Human

Entrez Gene: 28240 Mouse

Entrez Gene: 294329 Rat

Omim: 603749 Human

SwissProt: O94759 Human

SwissProt: Q5KTC0 Mouse

SwissProt: Q91YD4 Mouse

SwissProt: Q5G856 Rat

Unigene: 369759 Human

Unigene: 276762 Mouse

Unigene: 214495 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

TRPM2 屬于瞬時受體電位離子通道蛋白家族的M亞家族，是一種非選擇性的陽離子通道蛋白, 是離子通道蛋白參與了單核細胞的氧化應激應答反應，與老年性癡呆等神經退行疾病的發(fā)生與發(fā)展有著十分密切的聯(lián)系.













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