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CD6抗體
  • 產(chǎn)品貨號：
    BN40821R
  • 中文名稱：
    CD6抗體
  • 英文名稱：
    Rabbit anti-CD6 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40821R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,ELISA

  • BN40821R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱CD6
中文名稱CD6抗體
別    名CD_antigen=CD6; CD6; CD6 antigen Tp120; CD6_HUMAN; FLJ44171; OX52; T cell differentiation antigen CD6; T-cell differentiation antigen CD6; T12; TP120.  
研究領(lǐng)域細(xì)胞生物  干細(xì)胞  淋巴細(xì)胞  t-淋巴細(xì)胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量70kDa
細(xì)胞定位細(xì)胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD6:251-350/668 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹CD6 is a type I membrane protein expressed by thymocytes, mature T cells, a subset of B cells known as B1 cells, and some cells in the brain. CD6 is a member of the scavenger receptor cysteine rich (SRCR) family of proteins, which includes the leukocyte antigen CD5. The extracellular domain of CD6 is composed of three SRCR domains and has the same domain organization as CD5. The ligand for CD6 is CD166 also known as activated leukocyte cell adhesion molecule. Through its interaction with CD166 in the thymus, CD6 may have a role in T cell development.

Function:
Involved in cell adhesion. Binds to CD166.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

Post-translational modifications:
After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
Contains intrachain disulfide bond(s).

Similarity:
Contains 3 SRCR domains.

SWISS:
P30203

Gene ID:
923

Database links:

Entrez Gene: 923 Human

Entrez Gene: 25752 Rat

Omim: 186720 Human

SwissProt: P30203 Human

Unigene: 744366 Human

Unigene: 57361 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD6是I型整合膜糖蛋白,屬于SRCRSF（ scavenger receptor cysteine-rich superfamily）成員。CD6在外周血T細(xì)胞和髓質(zhì)的胸腺細(xì)胞表面表達(dá),也表達(dá)在皮質(zhì)的胸腺細(xì)胞、B1細(xì)胞、某些NK細(xì)胞、腦細(xì)胞、T細(xì)胞或B細(xì)胞的慢性白血病細(xì)胞上。 CD6參與T細(xì)胞活化,調(diào)節(jié)T細(xì)胞功能和介導(dǎo)細(xì)胞-細(xì)胞間的粘附。CD6分子可與TCR/CD3形成復(fù)合體，參與免疫突觸（immunological synapse，IS）的形成。
在自身性免疫性疾病發(fā)病機(jī)制中，T細(xì)胞增殖活化和遷移過程起著重要作用。基于CD6分子在淋巴細(xì)胞成熟、活化和增殖中的重要作用，阻斷CD6分子的功能可為類風(fēng)濕性關(guān)節(jié)炎、銀屑病等自身免疫的治療提供新的治療手段和方法.


















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