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RNA聚合酶I抗體
  • 產(chǎn)品貨號(hào)：
    BN40795R
  • 中文名稱：
    RNA聚合酶I抗體
  • 英文名稱：
    Rabbit anti-UBF1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40795R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Cow) 推薦應(yīng)用：WB,ELISA

  • BN40795R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Cow) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱UBF1
中文名稱RNA聚合酶I抗體
別    名UBF; NOR 90; Nucleolar transcription factor 1; UBF 1; UBF-1; UBF; UBTF; Autoantigen NOR-90; Upstream-binding factor 1; Upstream binding factor 1; upstream binding transcription factor, RNA polymerase I; UBF1_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量89kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human UBF1:51-150/764 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

Function:
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element.

Subcellular Location:
Nucleus

Post-translational modifications:
Phosphorylated and activated by PIK3CA.

Similarity:
Contains 6 HMG box DNA-binding domains.

SWISS:
P17480

Gene ID:
7343

Database links:

Entrez Gene: 7343 Human

Entrez Gene: 21429 Mouse

Entrez Gene: 25574 Rat

Omim: 600673 Human

SwissProt: P17480 Human

SwissProt: P25976 Mouse

SwissProt: P25977 Rat

Unigene: 89781 Human

Unigene: 2845 Mouse

Unigene: 22469 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.