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細(xì)胞質(zhì)膜微囊蛋白-1抗體
  • 產(chǎn)品貨號：
    BN40760R
  • 中文名稱：
    細(xì)胞質(zhì)膜微囊蛋白-1抗體
  • 英文名稱：
    Rabbit anti-Caveolin-1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40760R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB

  • BN40760R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱Caveolin-1
中文名稱細(xì)胞質(zhì)膜微囊蛋白-1抗體
別    名opamine D3 receptor; Caveolin1; Caveolin 1; 3 dopamine receptor; D; Dopamine receptor D3; DRD; ETM1; FET1; Cav-1; ETM1; CAV 1; CAV1; CAV1_HUMAN.  
研究領(lǐng)域信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Caveolin-1:2-80/178 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq].

Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

Subunit:
Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK.

Subcellular Location:
Golgi apparatus membrane;Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

Tissue Specificity:
Expressed in muscle and lung, less so in liver, brain and kidney.

Post-translational modifications:
The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.

DISEASE:
Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.

Similarity:
Belongs to the caveolin family.

SWISS:
Q03135

Gene ID:
857

Database links:

Entrez Gene: 403980 Dog

Entrez Gene: 857 Human

Entrez Gene: 12389 Mouse

Entrez Gene: 25404 Rat

Omim: 601047 Human

SwissProt: P33724 Dog

SwissProt: Q03135 Human

SwissProt: P49817 Mouse

SwissProt: P41350 Rat

Unigene: 3850 Dog

Unigene: 74034 Human

Unigene: 28278 Mouse

Unigene: 470537 Mouse

Unigene: 22518 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信號傳導(dǎo)（Signaling Intermediates）
Caveolin-1（小凹蛋白）是細(xì)胞生長相關(guān)信號途徑及腫瘤發(fā)生發(fā)展過程中重要的抑制因子，Caveolae是細(xì)胞膜內(nèi)的特殊膜結(jié)構(gòu)，參與包括細(xì)胞的分子運輸、細(xì)胞粘附和信號轉(zhuǎn)導(dǎo)在內(nèi)的多種細(xì)胞活動。Caveolin-1是Caveolae中重要的結(jié)構(gòu)蛋白，抑制細(xì)胞生長，與多種人類腫瘤發(fā)生發(fā)展相關(guān)的信號分子相互作用。Caveolin在信號轉(zhuǎn)導(dǎo)的整合中起支架蛋白的作用。Caveolin構(gòu)成了一個蛋白家族，他們是細(xì)胞質(zhì)膜中發(fā)夾樣結(jié)構(gòu)域的主要結(jié)構(gòu)成分。Caveolin在信號轉(zhuǎn)導(dǎo)的整合中起支架蛋白的作用。至今已經(jīng)鑒定了3種Caveolin （Caveolin-1、2 和3），它們具有不同的組織分布。Caveolin-1涉及乳腺上皮細(xì)胞增生的發(fā)病機制。該抗體可識別α和β型Caveolin-1。


























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