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谷胱甘肽S轉移酶A3抗體
  • 產(chǎn)品貨號：
    BN40741R
  • 中文名稱：
    谷胱甘肽S轉移酶A3抗體
  • 英文名稱：
    Rabbit anti-GSTA3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40741R-100ul

    100ul

    ￥2360.00

    交叉反應：Rat(predicted:Mouse) 推薦應用：WB

  • BN40741R-200ul

    200ul

    ￥3490.00

    交叉反應：Rat(predicted:Mouse) 推薦應用：WB

產(chǎn)品描述

英文名稱GSTA3
中文名稱谷胱甘肽S轉移酶A3抗體
別    名Glutathione S alkyltransferase A3; Glutathione S aralkyltransferase A3; Glutathione S aryltransferase A3; Glutathione S transferase A3 3; Glutathione S transferase A3; Glutathione S transferase alpha 3; Glutathione transferase alpha 3; GST class alpha; GST class alpha member 3; GSTA 3; GSTA3 3; GTA 3; GTA3; GTA-3; MGC22232; S (hydroxyalkyl)glutathione lyase A3; GSTA3_HUMAN.  
研究領域細胞生物  免疫學  信號轉導  轉錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Rat,  (predicted: Mouse, )
產(chǎn)品應用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse GSTA3:51-150/221 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. Glutathione S-transferase A3 (GSTA3) belongs to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. GSTA3 catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones.

Function:
Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles. Catalyzesisomerization reactions that contribute to the biosynthesis ofsteroid hormones. Efficiently catalyze obligatory double-bondisomerizations of delta(5)-androstene-3,17-dione anddelta(5)-pregnene-3,20-dione, precursors to testosterone andprogesterone, respectively.

Subunit:
Homodimer.

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the GST superfamily. Alpha family.
Contains 1 GST C-terminal domain.
Contains 1 GST N-terminal domain.

SWISS:
P30115

Gene ID:
14859

Database links:

Entrez Gene: 2940 Human

Entrez Gene: 14859 Mouse

Entrez Gene: 24421 Rat

Omim: 605449 Human

SwissProt: Q16772 Human

SwissProt: P30115 Mouse

SwissProt: P04904 Rat

Unigene: 102484 Human

Unigene: 394593 Mouse

Unigene: 10460 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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