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激活素受體2A抗體
  • 產(chǎn)品貨號(hào)：
    BN40737R
  • 中文名稱：
    激活素受體2A抗體
  • 英文名稱：
    Rabbit anti-ACVR2A Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN40737R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB

  • BN40737R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱ACVR2A
中文名稱激活素受體2A抗體
別    名Activin receptor 2A; Activin receptor type 2A; ACTR 2; ACTR IIA; ACTR2; ActRIIa; Acvr 2; Acvr 2A; Acvr2; Acvr2a; OTTHUMP00000197918; ACVR2A; Activin receptor type-2A.  
研究領(lǐng)域轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse ACVR2A:1-100/513 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. Activin has been suggested to be an autocrine/paracrine regulator in the human placenta. The presence of ACVR2 mRNA has been deomnstrated in human trophoblast cells and there is also evidence of expression of the gene in human brain and ovary.

Function:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Subunit:
Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain.

SWISS:
P27038

Gene ID:
11480

Database links:

Entrez Gene: 92 Human

Entrez Gene: 11480 Mouse

Entrez Gene: 29263 Rat

Omim: 102581 Human

SwissProt: P27037 Human

SwissProt: P27038 Mouse

SwissProt: P38444 Rat

Unigene: 470174 Human

Unigene: 314338 Mouse

Unigene: 161783 Ra



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

激活素受體ⅡA- ARIP2a屬于ARIP家族新成員，在腦組織、垂體、睪丸中表達(dá)較高，胰腺、卵巢組織中有表達(dá)。




















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