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Rap1A抗體
  • 產(chǎn)品貨號：
    BN40734R
  • 中文名稱：
    Rap1A抗體
  • 英文名稱：
    Rabbit anti-RAP1A Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40734R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB

  • BN40734R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱RAP1A
中文名稱Rap1A抗體
別    名C21KG; RAP1; G 22K; G-22K; GTP binding protein smg p21A; GTP-binding protein smg p21A; KREV 1; KREV-1; KREV1; OTTHUMP00000013741; RAP 1A; RAP1; RAP1A; RAP1A member of RAS oncogene family; RAP1A_HUMAN; Ras related protein Krev 1; Ras related protein Rap 1A; RAS related protein RAP1A; Ras-related protein Krev-1; Ras-related protein Rap-1A; SMGP21; rap1a; RAS-related protein-1a precursor; Rap1A-retro2; RAP1A, member of RAS oncogene family.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  G蛋白信號  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human RAP1A:1-100/184 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

Function:
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

Subunit:
Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain)

Subcellular Location:
Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions. Colocalized with RAPGEF2 in the perinuclear region.

Similarity:
Belongs to the small GTPase superfamily. Ras family.

SWISS:
P62834

Gene ID:
5906

Database links:

Entrez Gene: 5906 Human

Entrez Gene: 109905 Mouse

Entrez Gene: 295347 Rat

Omim: 179520 Human

SwissProt: P62834 Human

SwissProt: P62835 Mouse

SwissProt: P62836 Rat

Unigene: 190334 Human

Unigene: 458171 Mouse

Unigene: 106321 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

RAP1A 是RAS癌基因家族成員，在調(diào)節(jié)細(xì)胞增生和粘附中有重要作用.經(jīng)研究發(fā)現(xiàn),Rap1和它的調(diào)節(jié)子SPA-1在很多惡性腫瘤的發(fā)生、發(fā)展中起到一定的作用。定位于胞漿、胞膜。





















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