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自噬相關蛋白13抗體
  • 產(chǎn)品貨號：
    BN40726R
  • 中文名稱：
    自噬相關蛋白13抗體
  • 英文名稱：
    Rabbit anti-ATG13 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40726R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Rabbit,Sheep) 推薦應用：IHC-P

  • BN40726R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Rabbit,Sheep) 推薦應用：IHC-P

產(chǎn)品描述

英文名稱ATG13
中文名稱自噬相關蛋白13抗體
別    名ATG13 autophagy related 13 homolog; ATG13_HUMAN; Autophagy related protein 13; Autophagy-related protein 13; FLJ20698; KIAA0652.  
研究領域腫瘤  新陳代謝  線粒體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Rabbit, Sheep, )
產(chǎn)品應用IHC-P=1:400-800 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
細胞定位細胞漿 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ATG13:41-140/517 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.

Function:
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Subunit:
Part of a complex consisting of ATG13, ULK1 and RB1CC1. Interacts with ATG101. Interacts with ULK1 (via C-terminus). Interacts with ULK2 (via C-terminus).

Subcellular Location:
Cytoplasm, cytosol.Preautophagosomal structure.

Post-translational modifications:
Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria.

Similarity:
Belongs to the ATG13 metazoan family.

SWISS:
O75143

Gene ID:
9776

Database links:

Entrez Gene: 507340 Cow

Entrez Gene: 9776 Human

Entrez Gene: 51897 Mouse

Entrez Gene: 362164 Rat

Entrez Gene: 393405 Zebrafish

SwissProt: Q08DY8 Cow

SwissProt: O75143 Human

SwissProt: Q91YI1 Mouse

SwissProt: Q7SYE0 Zebrafish

Unigene: 127403 Human

Unigene: 28492 Mouse

Unigene: 98797 Rat

Unigene: 82470 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.