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磷酸化鋅指轉(zhuǎn)錄因子Slug+SNAIL抗體
  • 產(chǎn)品貨號(hào)：
    BN40725R
  • 中文名稱：
    磷酸化鋅指轉(zhuǎn)錄因子Slug+SNAIL抗體
  • 英文名稱：
    Rabbit anti-phospho-SNAIL + SLUG (Ser246) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40725R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：IHC-P

產(chǎn)品描述

英文名稱phospho-SNAIL + SLUG (Ser246)
中文名稱磷酸化鋅指轉(zhuǎn)錄因子Slug+SNAIL抗體
別    名SNAIL + SLUG (phospho S246); p-SNAIL + SLUG (phospho S246); SNAIL + SLUG (phospho S246 + S251); SNAIL + SLUG (phospho Ser246 + Ser251); phospho-SNAIL(Ser246) + SLUG(Ser251); phospho-SNAIL(Ser246) + SLUG(Ser251); dJ710H13.1; MGC10182; Neural crest transcription factor Slug; Protein sna; Protein snail homolog 1; Protein snail homolog 2; Protein snail homolog; Slug homolog zinc finger protein; Slug zinc finger protein; SLUGH; SLUGH 1; SLUGH1; SLUGH2; SNA; Sna protein; SNAH; SNAI 2; snai1; SNAI1_HUMAN; Snai2; SNAI2_HUMAN; Snail 2; Snail homolog 1 (Drosophila); Snail homolog 2; Snail2; WS 2D; WS2D; Zinc finger protein SLUG; Zinc finger protein SNAI1; Zinc finger protein SNAI2.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域腫瘤  心血管  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用IHC-P=1:400-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human phospho-SNAIL + SLUG (Ser246) :TF(p-S)RM 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

Function:
Involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm. Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.

Subunit:
Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3.

Subcellular Location:
Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.

Tissue Specificity:
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Post-translational modifications:
Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination.
Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation.
O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein.

Similarity:
Belongs to the snail C2H2-type zinc-finger protein family.
Contains 4 C2H2-type zinc fingers.

SWISS:
O95863

Gene ID:
6615

Database links:

Entrez Gene: 6615 Human

Entrez Gene: 20613 Mouse

Entrez Gene: 116490 Rat

Omim: 604238 Human

SwissProt: O95863 Human

SwissProt: Q02085 Mouse

Unigene: 48029 Human

Unigene: 2093 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Snail蛋白主要用于消化系統(tǒng)腫瘤方面的研究