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纖維母細(xì)胞生長(zhǎng)因子7抗體
  • 產(chǎn)品貨號(hào)：
    BN40715R
  • 中文名稱：
    纖維母細(xì)胞生長(zhǎng)因子7抗體
  • 英文名稱：
    Rabbit anti-KGF Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40715R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB

  • BN40715R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱KGF
中文名稱纖維母細(xì)胞生長(zhǎng)因子7抗體
別    名FGF 7; FGF7; FGF-7; Fibroblast Growth Factor 7;HBGF 7; HBGF7; HBGF-7; Keratinocyte growth factor precursor; Heparin binding growth factor 7; Keratinocyte Growth Factor; FGF7_HUMAN; Heparin-binding growth factor 7.  
研究領(lǐng)域腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KGF:32-110/194 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹KGF is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.

Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Subunit:
Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

Subcellular Location:
Secreted.

Tissue Specificity:
Epithelial cell.

Similarity:
Belongs to the heparin-binding growth factors family.

SWISS:
P21781

Gene ID:
2252

Database links:

Entrez Gene: 2252 Human

Entrez Gene: 14178 Mouse

Entrez Gene: 29348 Rat

Omim: 148180 Human

SwissProt: P21781 Human

SwissProt: P36363 Mouse

SwissProt: Q02195 Rat

Unigene: 567268 Human

Unigene: 330557 Mouse

Unigene: 98842 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

KGF/FGF7 (Fibroblast growth factor 7) 又稱：HBGF-7 纖維母細(xì)胞生長(zhǎng)因子7，是FGF家族的主要成員之一。 FGF家族參與細(xì)胞生長(zhǎng)、組織修復(fù)、胚胎生長(zhǎng)發(fā)育、組織器官的形成、腫瘤的生長(zhǎng)和侵潤(rùn)等諸多生理病理功能。 成纖維細(xì)胞生長(zhǎng)因子7的促增生作用主要來源于角化上皮細(xì)胞而不是間質(zhì)細(xì)胞和內(nèi)皮細(xì)胞，因此人們又稱之為：角化上皮細(xì)胞生長(zhǎng)因子（KGF）。