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鈣粘蛋白相關(guān)蛋白受體BTR1抗體
  • 產(chǎn)品貨號：
    BN40691R
  • 中文名稱：
    鈣粘蛋白相關(guān)蛋白受體BTR1抗體
  • 英文名稱：
    Rabbit anti-BTR1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40691R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB

  • BN40691R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱BTR1
中文名稱鈣粘蛋白相關(guān)蛋白受體BTR1抗體
別    名BT R1; NaBC1; SLC4A11; sodium bicarbonate transporter-like protein 11; solute carrier family 4 member 11; S4A11_HUMAN.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量100kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human BTR1 :61-160/891 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹BtR1 is a cadherin receptor from the tobacco hornworm Manduca sexta.

Function:
Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.

Subunit:
Homodimer.

Subcellular Location:
Cell membrane. Membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.

Post-translational modifications:
Glycosylated.

DISEASE:
Corneal dystrophy and perceptive deafness (CDPD) [MIM:217400]: An ocular disease characterized by the association of corneal clouding with progressive perceptive hearing loss. Note=The disease is caused by mutations affecting the gene represented in this entry.
Corneal dystrophy, endothelial 2, autosomal recessive (CHED2) [MIM:217700]: A congenital corneal dystrophy characterized by thickening and opacification of the cornea, altered morphology of the endothelium, and secretion of an abnormal collagenous layer at the Descemet membrane. Note=The disease is caused by mutations affecting the gene represented in this entry.
Corneal dystrophy, Fuchs endothelial, 4 (FECD4) [MIM:613268]: A corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the anion exchanger (TC 2.A.31) family.

SWISS:
Q8NBS3

Gene ID:
83959

Database links:

Entrez Gene: 83959 Human

Entrez Gene: 532407 Cow

Entrez Gene: 269356 Mouse

Entrez Gene: 311423 Rat

Omim: 610206 Human

SwissProt: Q8NBS3 Human

SwissProt: A2AJN7 Mouse

Unigene: 105607 Human

Unigene: 441391 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.






















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