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葡萄糖轉(zhuǎn)運蛋白3抗體
  • 產(chǎn)品貨號：
    BN40690R
  • 中文名稱：
    葡萄糖轉(zhuǎn)運蛋白3抗體
  • 英文名稱：
    Rabbit anti-GLUT3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40690R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB

  • BN40690R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱GLUT3
中文名稱葡萄糖轉(zhuǎn)運蛋白3抗體
別    名facilitated glucose transporter member 3; Glucose Transporter GLUT3 ; FLJ90380; Glucose Transporter Type 3; Glucose transporter type 3 brain; GLUT 3; GLUT-3; GTR3_HUMAN; SLC2A3; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3; Solute carrier family 2.  
研究領(lǐng)域腫瘤  細胞生物  信號轉(zhuǎn)導  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse GLUT3 :431-496/496 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹may act as a glucose transporter in neurons; may mediate increasd glucose uptake in response to neuronal injury. Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response to insulin and IGF1 induced signaling. GLUT3 is detectable in a few normal cell type spermatids in testis with active spermatogenesis, placental trophoblast membranes, and neurons in brain. GLUT3 staining is also detectable in human cancers including those of the ovary, lung, and testis. Alternative names: FLJ90380; Glucose Transporter Type 3; Glucose transporter type 3 brain; GLUT 3; GLUT3; SLC2A3; Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3.

Function:
Facilitative glucose transporter. Probably a neuronal glucose transporter.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Melanosome.

Tissue Specificity:
Highly expressed in brain. Expressed in many tissues.

Similarity:
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

SWISS:
P11169

Gene ID:
6515

Database links:

Entrez Gene: 6515 Human

Entrez Gene: 20527 Mouse

Entrez Gene: 25551 Rat

Omim: 138170 Human

SwissProt: P11169 Human

SwissProt: P32037 Mouse

SwissProt: Q07647 Rat

Unigene: 419240 Human

Unigene: 395108 Mouse

Unigene: 95055 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

交換和轉(zhuǎn)運（Trafficking and Transport） GLUT-3屬于溶質(zhì)運載蛋白家族成員（solute carrier family），主要功能是轉(zhuǎn)載葡萄糖進入上皮細胞。 目前主要用于糖尿病腎病和視網(wǎng)膜病變的研究，也是腎小球系膜細胞上的主要葡萄糖轉(zhuǎn)運體。GLUT3的功能狀態(tài)直接影響系膜細胞的糖代謝及功能變化。 近期，研究人員也用來區(qū)別一些良、惡性腫瘤的鑒別。