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GDNF家族受體α-1抗體
  • 產(chǎn)品貨號：
    BN40686R
  • 中文名稱：
    GDNF家族受體α-1抗體
  • 英文名稱：
    Rabbit anti-GDNFRA Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40686R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Rabbit) 推薦應用：WB

  • BN40686R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Rabbit) 推薦應用：WB

產(chǎn)品描述

英文名稱GDNFRA
中文名稱GDNF家族受體α-1抗體
別    名GDNF Receptor alpha 1; GFRa-1; GFR alpha; GDNFR alpha; TmR1; GFR alpha-1; RETL1; RET ligand 1; TGF-beta related neurotrophic factor receptor-1; AU042498; DKFZp313E1012; DKFZp686J0156; FLJ10561; FLJ31546; GDNFR; Gdnfr alpha; GFR-ALPHA-1; GFRA1; GRFA1; LOC143381; MGC23045; Ret; RET1L; RETL1; TRNR1; GFRA1_HUMAN; GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; TGF-beta-related neurotrophic factor receptor 1.  
研究領域免疫學  神經(jīng)生物學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GDNFRA:81-180/465 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq]

Function:
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.

Subunit:
2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Similarity:
Belongs to the GDNFR family.

SWISS:
P56159

Gene ID:
2674

Database links:

Entrez Gene: 2674 Human

Entrez Gene: 14585 Mouse

Entrez Gene: 25454 Rat

Omim: 601496 Human

SwissProt: P56159 Human

SwissProt: P97785 Mouse

SwissProt: Q62997 Rat

Unigene: 591913 Human

Unigene: 88489 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GFRα-1是由68個氨基酸組成的蛋白，廣泛表達于中樞神經(jīng)系統(tǒng)和外周器官?；钚詠唵挝挥蓛蓚€GFRα-1分子中間由二硫鍵連接而成的復合物。屬于GDNFR 家族成員。














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