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整合素alpha E2 抗體
  • 產(chǎn)品貨號：
    BN40677R
  • 中文名稱：
    整合素alpha E2 抗體
  • 英文名稱：
    Rabbit anti-Integrin alpha E Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40677R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應(yīng)用：WB,IHC-F,IF,Flow-Cyt,ELISA

  • BN40677R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Rabbit) 推薦應(yīng)用：WB,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Integrin alpha E
中文名稱整合素alpha E2 抗體
別    名Itgae; A530055J10; alpha-E1; alpha-M290; aM290; CD103; MGC183601; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide. ITAE_HUMAN; Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; Integrin alpha-E heavy chain; integrin alpha-E precursor.   
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞粘附分子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量110/128kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Integrin alpha-E heavy chain:1101-1179/1179 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹CD103/Integrin alpha E is a new member of the integrin series of adhesion molecules containing the beta7 subunit. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs, appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis and periphery. In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. Integrin alpha E is a heterodimer comprising a 150kDa alpha chain and a 120kDa beta chain. Integrin alpha E is expressed by approximately 1% of peripheral blood lymphocytes, activated T lymphocytes and by hairy cell leukaemia cells. The antigen is also expressed by intraepithelial lymphocytes.

Function:
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Tissue Specificity:
Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

SWISS:
P38570

Gene ID:
3682

Database links:

Entrez Gene: 3682 Human

Omim: 604682 Human

SwissProt: P38570 Human

Unigene: 513867 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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