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金屬蛋白酶組織抑制因子-2抗體
  • 產品貨號：
    BN40665R
  • 中文名稱：
    金屬蛋白酶組織抑制因子-2抗體
  • 英文名稱：
    Rabbit anti-TIMP-2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN40665R-100ul

    100ul

    ￥2360.00

    交叉反應：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40665R-200ul

    200ul

    ￥3490.00

    交叉反應：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱TIMP-2
中文名稱金屬蛋白酶組織抑制因子-2抗體
別    名Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.  
研究領域腫瘤  心血管  細胞生物  神經生物學  信號轉導  細胞凋亡  生長因子和激素  合成與降解  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
細胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TIMP-2:141-220/220 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008].

Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Subunit:
Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

Subcellular Location:
Secreted.

Post-translational modifications:
The activity of TIMP2 is dependent on the presence of disulfide bonds.

Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.

SWISS:
P16035

Gene ID:
7077

Database links:

Entrez Gene: 282093 Cow

Entrez Gene: 100135629 Guinea pig

Entrez Gene: 7077 Human

Entrez Gene: 21858 Mouse

Entrez Gene: 100008689 Rabbit

Entrez Gene: 29543 Rat

Omim: 188825 Human

SwissProt: P16368 Cow

SwissProt: Q9WUC6 Guinea pig

SwissProt: P16035 Human

SwissProt: P25785 Mouse

SwissProt: Q9TRZ7 Rabbit

SwissProt: P30121 Rat

Unigene: 633514 Human

Unigene: 206505 Mouse

Unigene: 10161 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解（Synthesis and Degradation）
TIMP-2與TIMP-1一樣是基質金屬蛋白酶的抑制酶，其功能與MMP相反，能抑制腫瘤細胞的浸潤和轉移，主要用于各種惡性腫瘤如乳腺癌等的研究。TIMP-2又稱為CSC-21K，是一種21-24kDa的糖蛋白，在多種組織細胞中表達，它可以和MMPs家族成員以共價鍵方式形成復合物，從而發(fā)揮其抑制作用。在正常生理條件下，MMPs和TIMPs之間的平衡狀態(tài)是維持細胞外基質正常狀態(tài)所必需的，一旦它們之間的比例失調，就會造成一系列的病理狀態(tài)。


















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