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G蛋白偶聯(lián)受體49抗體
  • 產(chǎn)品貨號(hào)：
    BN40642R
  • 中文名稱(chēng)：
    G蛋白偶聯(lián)受體49抗體
  • 英文名稱(chēng)：
    Rabbit anti-GPR49/LGR5 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40642R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,Flow-Cyt,ELISA

  • BN40642R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱(chēng)GPR49/LGR5
中文名稱(chēng)G蛋白偶聯(lián)受體49抗體
別    名G protein coupled receptor 49; G-protein coupled receptor 49; G-protein coupled receptor 67; GPCR GPR49; G protein coupled receptor 67; FEX; g protein-coupled receptor fex; G-protein coupled receptor HG38; GPR 49; GPR 67; GPR67; Leucine rich repeat containing G protein coupled receptor 5; HG 38; HG38; LGR5; LGR5_HUMAN; MGC117008; Leucine-rich repeat-containing G-protein coupled receptor 5; LGR 5; Orphan G protein coupled receptor HG38.  
研究領(lǐng)域腫瘤  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞凋亡  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量98kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GPR49/LGR5:211-310/907 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Function:
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Subunit:
Identified in a complex composed of RNF43, LGR5 and RSPO1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein

Tissue Specificity:
Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.

Similarity:
Belongs to the G-protein coupled receptor 1 family.
Contains 16 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.

SWISS:
O75473

Gene ID:
8549

Database links:

Entrez Gene: 8549 Human

Entrez Gene: 14160 Mouse

Entrez Gene: 299802 Rat

Omim: 606667 Human

SwissProt: O75473 Human

SwissProt: Q9Z1P4 Mouse

Unigene: 658889 Human

Unigene: 42103 Mouse

Unigene: 214063 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Lgr5基因（Wnt細(xì)胞信號(hào)系統(tǒng)）是一種G蛋白偶聯(lián)受體，已經(jīng)被確定為幾種成年組織和癌癥中干細(xì)胞的一個(gè)獨(dú)特標(biāo)記。Lgr5最初是在結(jié)腸癌細(xì)胞中發(fā)現(xiàn)的，有報(bào)道稱(chēng)：在惡化前的小鼠腺瘤中也有發(fā)現(xiàn)，這說(shuō)明Lgr5很可能也是其他組織成體干細(xì)胞和癌癥干細(xì)胞的標(biāo)志物。