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高遷移率族蛋白B1抗體
  • 產(chǎn)品貨號：
    BN40615R
  • 中文名稱：
    高遷移率族蛋白B1抗體
  • 英文名稱：
    Rabbit anti-HMGB1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40615R-100ul

    100ul

    ￥2360.00

    交叉反應：Rat,Mouse,Human(predicted:Horse,Cow,Pig,Dog) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN40615R-200ul

    200ul

    ￥3490.00

    交叉反應：Rat,Mouse,Human(predicted:Horse,Cow,Pig,Dog) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱HMGB1
中文名稱高遷移率族蛋白B1抗體
別    名Amphoterin; High mobility group 1; High Mobility Group Box 1; High mobility group protein 1; High mobility group protein B1; HMG3; HMGB 1;HMGB-1; Hmgb1 protein; Nonhistone chromosomal protein HMG1; SBP 1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; HMGB1_MOUSE.  
研究領(lǐng)域腫瘤  細胞生物  免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
細胞定位細胞核 細胞漿 細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse HMGB1:61-150/215 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve dependent mechanism, inhibits HMGB1 release in experimental disease models

Function:
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.

Subunit:
Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2.

Subcellular Location:
Nucleus. Chromosome.

Similarity:
Belongs to the HMGB family.
Contains 2 HMG box DNA-binding domains.

SWISS:
P09429

Gene ID:
100862258

Database links:

Entrez Gene: 282691 Cow

Entrez Gene: 3146 Human

Entrez Gene: 100862258 Mouse

Entrez Gene: 15289 Mouse

Entrez Gene: 25459 Rat

Omim: 163905 Human

SwissProt: P10103 Cow

SwissProt: P09429 Human




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

近來的研究表明稱之為高遷移率族蛋白B-1（HMG-B1）的核內(nèi)結(jié)構(gòu)蛋白在核外表達時是一種有效的早期炎癥介質(zhì)。
高遷移性Ｂ１組蛋白（ＨＭＧＢ１）： 是一種核結(jié)合蛋白，在ＤＮＡ重組、修復、復制和基因轉(zhuǎn)錄中起作用。ＨＭＧＢ１也是巨噬細胞分泌的一種介質(zhì)。
此外，高遷移性Ｂ１組蛋白亦被受刺激的巨噬細胞或單核細胞主動分泌。在這一主動分泌過程中，HMGB1首先經(jīng)乙?；⒂珊藘?nèi)轉(zhuǎn)移至溶酶體內(nèi)，繼而在ATP和溶血磷脂膽堿兩種分泌信號指導下轉(zhuǎn)移至細胞外。由壞死細胞被動釋放的HMGB1和炎癥細胞主動分泌的HMGB1存在分子上的差異。胞外的HMGB1可作為細胞因子參與信號傳導，因為它既可識別Toll 樣受體（TLR）家族的一些成員，又能與識別晚期糖基化終末產(chǎn)物受體（RAGE）相作用。
HMGB1能啟動炎癥反應，包括產(chǎn)生多種細胞因子、對某些干細胞產(chǎn)生趨化作用、誘導血管粘附分子、削弱腸上皮細胞的功能等。