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MED28蛋白抗體
  • 產(chǎn)品貨號：
    BN40537R
  • 中文名稱：
    MED28蛋白抗體
  • 英文名稱：
    Rabbit anti-MED28 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40537R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF

  • BN40537R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱MED28
中文名稱MED28蛋白抗體
別    名EG1; Endothelial-derived protein 1; FKSG20; Magicin; med28; MED28_HUMAN; Mediator complex subunit 28; Mediator of RNA polymerase II transcription subunit 28; Mediator of RNA polymerase II transcription subunit 28; Mediator of RNA polymerase II transcription subunit 28; Merlin and Grb2-interacting cytoskeletal protein; Tumor angiogenesis marker EG-1.  
研究領(lǐng)域細胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
產(chǎn)品應(yīng)用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MED28:1-100/178 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Med28 is a 178 amino acid subunit of the Mediator complex that localizes to both nucleus and cytoplasm. Widely expressed with highest expression in vascular tissues such as placenta, testis and liver, Med28 participates in the regulation of Pol II-mediated gene expression and is thought to play a key role in signal regulation and cell proliferation. It is suggested that Med28 functions as a repressor of SMC (smooth muscle cell) differentiation and may be associated with abnormalities in SMC growth and differentiation, including atherosclerosis, asthma, hypertension and smooth muscle tumors.

Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.

Subcellular Location:
Nucleus. Cytoplasm. Membrane. According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.

Tissue Specificity:
Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.

Similarity:
Belongs to the Mediator complex subunit 28 family.

SWISS:
Q9H204

Gene ID:
610311

Database links:

Entrez Gene: 80306 Human

Entrez Gene: 66999 Mouse

Omim: 610311 Human

SwissProt: Q9H204 Human

SwissProt: Q920D3 Mouse

Unigene: 434075 Human

Unigene: 644788 Human

Unigene: 283045 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.