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清道夫受體B1+B2抗體
  • 產(chǎn)品貨號(hào)：
    BN40489R
  • 中文名稱：
    清道夫受體B1+B2抗體
  • 英文名稱：
    Rabbit anti-Scavenger Receptor BI + BII Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40489R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN40489R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱Scavenger Receptor BI + BII
中文名稱清道夫受體B1+B2抗體
別    名85 kDa lysosomal membrane sialoglycoprotein; CD36 and LIMPII Analogous 1; CD36L1; CD36L2; CLA1; HLGP85; LGP85; LIMP II; Lysosome membrane protein II; MGC138242; SCARB1; SCARB2; Scavenger receptor class B member 2; Scavenger Receptor Class B Type I; SRBI; SRBII.  
研究領(lǐng)域腫瘤  心血管  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  新陳代謝  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量61kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Scavenger Receptor BI + BII:31-130/552 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Function:
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Subcellular Location:
Lysosome; lysosomal membrane; multi-pass membrane protein.

SWISS:
Q14108

Gene ID:
949

Database links:

Entrez Gene: 949 Human

Entrez Gene: 950 Human

Entrez Gene: 12492 Mouse

Entrez Gene: 20778 Mouse

Entrez Gene: 117106 Rat

Entrez Gene: 25073 Rat

Omim: 601040 Human

Omim: 602257 Human

SwissProt: Q14108 Human

SwissProt: Q8WTV0 Human

SwissProt: O35114 Mouse

SwissProt: Q61009 Mouse

SwissProt: P27615 Rat

SwissProt: P97943 Rat

Unigene: 298813 Human

Unigene: 349656 Human

Unigene: 592984 Human

Unigene: 282242 Mouse

Unigene: 297964 Mouse

Unigene: 399507 Mouse

Unigene: 410528 Mouse

Unigene: 3957 Rat

Unigene: 88169 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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